Our Technology

From citrus by-product to high purity CB1 and CB2 receptor ligands

Unlike plant extraction or biosynthetic approaches, our process is:

Our platform enables pharmaceutical-grade ligand production with precision, consistency, and environmental responsibility.

Limonene to Ligands

1. Catalytic Transformation

Our process begins with limonene, an abundant, low-cost industrial feedstock derived from orange peels.

Through a proprietary catalytic sequence, limonene is converted into a stable, air-tolerant molecular precursor protected by multiple patents.

This precursor forms the foundation of our platform.

2. Modular Ligand Construction

Using a series of catalytic transformations, including:

  • Selective functional group protection
  • Carbon–carbon bond formation
  • Controlled side-chain installation
  • Catalytic cross-coupling strategies
  • Aqueous work-up and purification

We convert the precursor into a diverse library of CB1 and CB2 ligands and structural analogues.

3. Catalytic Transformation

Our process delivers:

  • ≥99% purity
  • Single-component products
  • No plant contaminants
  • No batch variability
  • cGMP-ready material


Catalysts and solvents are recovered, recycled, or reused through standard lifecycle management protocols, reinforcing our green chemistry approach.

WHY CATALYSIS MATTERS

Traditional agriculture, biosynthesis and stoichiometric synthesis can be inconsistent, more expensive and have downstream isolation and scalability issues. 

Our process is fast and efficient while retaining high purity, single-component end products which have been demonstrated at scale under cGMP conditions. The process has been approved by Health Canada and is fully scalable to multi-ton outputs. 

Abstract DNA Strand
Our Approach

Kare’s catalytic approach provides a more efficient & reliable solution

Platform Capabilities

Broad Ligand Library Access

Production of diverse CB1- and CB2-targeting molecules from a single precursor backbone.

Tunable Receptor Selectivity

Fine adjustment of molecular architecture to modulate receptor binding profiles.

Novel Chemical Entities (NCEs)

Development of structurally optimized ligands beyond naturally occurring scaffolds.

Isotopically Labeled & Specialized Variants

Deuterated and carbon-labeled compounds for research and clinical development.

Sustainable Chemistry

Green chemistry is built into our process design:

  • Waste feedstock starting material

  • Catalytic (not stoichiometric) transformations

  • Solvent recovery and reuse

  • Low-energy synthetic cycles

Our goal is to make advanced therapeutics without compromising environmental responsibility.

Our Result

A scalable, industrialized, and defensible platform for the synthesis of high-purity CB1 and CB2 ligands, capable of supporting both B2B pharmaceutical supply and internal drug development.